Glossary
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β catenin: Protein involved in the Wnt signalling pathway, degraded by slimb in the absence of Wnt.
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BMP-4: is a member of the Bone Morphogenetic protein family, which is apart of the TGFβ superfamily.
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Brachyury: a transcription factor that induces mesodermal fate in cells.
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Cereberus: BMP antagonists expressed by the Spemann Organiser. Responsible for differentiation of the mesoderm.
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Chordin: BMP antagonists expressed by the Spemann Organiser. Responsible for differentiation of the mesoderm.
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Cortical rotation: Movement of the membrane brought about by sperm entering the oocyte.
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Destruction Complex: Responsible for the breakdown of β catenin in the absence of Wnt.
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Dishevelled: Recruited to Frizzled in the presence of Wnt.
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Follistatin: BMP antagonists expressed by the Spemann Organiser. Responsible for differentiation of the mesoderm.
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Frizzled: A cell surface receptor in the Wnt/Wingless signalling pathway.
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Goosecoid: Gene activated by Siamois causing the expression of several diffusible molecules. Regulates its own expression, sustaining the Organiser.
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Mesoderm: is a primary germ layer, later becoming neural tissue and a variety of organs.
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Nieuwkoop center: group of cells which express siamois and induce the formation of the spemann organiser.
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Nodal: a member of the TGFβ superfamily and is triggered by VegT and Vg1.
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Noggin : BMP antagonists expressed by the Spemann Organiser. Responsible for differentiation of the mesoderm.
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Siamois: Gene which encodes for the secreted protein 'siamois'. Activated by high levels of β catenin.
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Spemann Organiser: a group of cells which express goosecoid and BMP antagonist, so involved in patterning the embryo.
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VegT: Maternal protien involved in Nodal expression.
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Vg1: is a member of the TGFβ superfamily and involved in Nodal expression.
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Wnt: protein involved in siganlling via Frizzled receptor, known to be involved in development and cancer.